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This research was for investigating the physiological effect caused by genetic disorder and others. Serum protein, serum LDH, and serum CPK were analyzed on Fragile X syndrome patients, carriers, unclassified mental retardees, and Down´s syndrome patients by cellulose acetate plate electrophoresis. Also enzyme activity of LDH and CPK were measured. Significant differences were observed between normal group and mental retardees in compositions of serum protein, serum LDH, serum CPK, and enzyme activities. Mean percentages of albumin were 53.70±7.73% for Fragile X syndrome patients, 57.09±7.73% for carriers, 47.33±6.06% for unclassified mental retardees, 50.19± 15.72% for Down´s syndrome patients. Mean percentages of γ-globulin were 19.64±6.71% for Fragile X syndrome patients, 19.24±3.38% for carries, 25.66±4.74 for unclassified mental retardees, 23.41±6.08% for Down´s syndrome patients. Mean percentages of LDH3 were 27.76±2.72% for Fragile X syndrome patients, 22.70±2.76% for carriers, 25.42±1.26% for unclassified mental retardees, 27.72±2.58% for Down´s syndrome patients. Mean percentages of LDH4 were 2.70±2.04 for Fragile X syndrome patients, 3.79±2.74% for carriers, so both of them were significantly lower than normal(P<0.05). Mean percentages of CK-MB were 3.96±5.56% for Fragile X syndrome patients, 8.80±7.92%. Mean percentages of CK-MM were 95.81±5.50% for Fragile X syndrome patients, 91.20±7.92% for carriers. These results showed that significant abnormal compositions of blood proteins might be caused by genetic disorder. However, further analysis of many patients will be needed for clear conclusion.
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